ดร.จารุ เตชะเลิศไพศาล

ดร. จารุ เตชะเลิศไพศาล

Dr. Jaru Taechalertpaisarn

 

อาจารย์ประจำ

 

โทรศัพท์ 02-576-6000 ต่อ 7285
Email: [email protected]    

การศึกษา

2018     Ph.D.   (Chemistry)
Department of Chemistry, Texas A&M University

2010    วท.บ.   (เคมี) 
คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย

ความเชี่ยวชาญ/งานวิจัยที่สนใจ

Organic Chemistry, Medicinal Chemistry, Peptide Chemistry, Solid-phase Synthesis, Combinatorial Synthesis, High-throughput Screening, Molecular Modeling, Cancer Research

บทความวิชาการ/งานวิจัยที่ได้รับการตีพิมพ์
  1. Taechalertpaisarn, J.; Engstrom, A.; Sajimon, M.; Rabbitts, B. M.; Serrão, V. H. B.; Ono, S.; Raskatov, J. A.; Johnstone, T. C.; Lokey, R. S. (2026). Exploring Passive Permeability Profiles of Cyclic Heptapeptide Chemical Space Uncovers Bioactivity of Mortiamide Scaffold Driven by Colloidal Aggregation. ChemBioChem, 27, e70329. (https://doi.org/10.1002/cbic.70329)
  2. Koch, G.; Engstrom, A.; Taechalertpaisarn, J.; Faris, J.; Naylor, M; Ono, S.; Lokey, R. S. (2024). Chromatographic Determination of Lipophilic Permeability Efficiency Facilitates Rapid Identification of Passively Permeable Macrocyclic Peptide Scaffolds. J. Med. Chem., 67(21), 19612-19622. (https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01956)
  3. Faris, J. H.; Adaligil, E.; Popovych, N.; Ono, S.; Takahashi, M.; Nguyen, H.; Plise, E.; Taechalertpaisarn, J.; Lee, H.-W.; Koehler, M. F. T.; Cunningham, C. N.; Lokey, R. S. (2024). Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. J. Am. Chem. Soc., 146, 4582-4591. (https://pubs.acs.org/doi/10.1021/jacs.3c10949)
  4. Supabowornsathit, K.; Ditmangklo, B.; Faikhruea, K.; Choopara, I.; Junpra-ob, S.; Jaroenchuensiri, T.; Wongsuwan, S.; Aonbangkhen, C.; Somboonna, N.; Taechalertpaisarn, J.; Vilaivan, T. (2022). Dicationic Styryl Dyes for Colorimetric and Fluorescent Detection of Nucleic Acids. Sci. Rep., 12, 14250. (https://doi.org/10.1038/s41598-022-18460-w)
  5. Taechalertpaisarn, J.; Ono, S.; Okada, O.; Johnstone, T. C.; Lokey, R. S. (2022). A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding. J. Med. Chem., 65, 5072-5084. (https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00010)
  6. Arancillo, M.; Taechalertpaisarn, J.; Liang, X.; Burgess, K. (2021). Piptides: New, Easily Accessible Chemotypes For Interactions with Biomolecules. Angew. Chem. Int. Ed., 60, 6653-6659. (https://doi.org/10.1002/anie.202015203)
  7. Ditmangklo, B.; Taechalertpaisarn, J.; Vilaivan, T. (2019). Clickable Styryl Dyes for Fluorescence Labeling of Pyrrolidinyl PNA Probes for the Detection of Base Mutations in DNA. Org. Biomol. Chem., 17, 9712-9725. (https://doi.org/10.1039/C9OB01492F)
  8. Taechalertpaisarn, J.; Lyu, R.; Arancillo, M.; Lin, C.; Perez, L. M.; Ioerger, T. R.; Burgess, K. (2019). Correlations Between Secondary Structure- and Protein–Protein Interface-Mimicry: The Interface Mimicry Hypothesis. Org. Biomol. Chem., 17, 3267-3274. (https://doi.org/10.1039/C9OB00204A)
  9. Taechalertpaisarn, J.; Lyu, R.; Arancillo, M.; Lin, C.; Jiang, Z.; Perez, L. M.; Ioerger, T. R.; Burgess, K. (2019). Design Criteria for Minimalist Mimics of Protein-Protein Interface Segments. Org. Biomol. Chem., 17, 908-915. (https://doi.org/10.1039/C8OB02901F)
  10. Taechalertpaisarn, J.; Zhao, B.; Liang, X.; Burgess, K. (2018). Small Molecule Inhibitors of the PCSK9•LDLR Interaction. J. Am. Chem. Soc., 140, 3242-3249. (https://pubs.acs.org/doi/10.1021/jacs.7b09360)
  11. Li, X.; Taechalertpaisarn, J.; Xin, D.; Burgess, K. (2015). Protein-Protein Interface Mimicry by an Oxazoline Piperidine-2,4-dione. Org. Lett., 17, 632-635. (https://pubs.acs.org/doi/10.1021/ol5036547)
  12. Taechalertpaisarn, J.; Sriwarom, P.; Boonlua, C.; Yotapan, N.; Vilaivan, C.; Vilaivan, T. (2010). DNA-, RNA- and Self-paring Properties of Pyrrolidinyl Peptide Nucleic Acid with a (2’R,4’S)-Prolyl-(1S,2S)-2-aminocyclopentanecarboxylic Acid Backbone. Tetrahedron Lett., 51, 5822-5826. (https://doi.org/10.1016/j.tetlet.2010.08.102)
การนำเสนอผลงานวิชาการ
  1. Drug Discovery Chemistry, April 10th–13th 2023, San Diego, California USA. Poster presentation: Discovery of Novel Active Macrocyclic Peptides Through Permeable-First Perspective.
  2. Chemical Screening Center Grand Reopening Celebration & Research Symposium, May 5th 2023, Santa Cruz, California USA. Oral presentation: Discovery of Novel Active Macrocyclic Peptides Through Permeable-First Perspective.