ดร.อภิวรรณ อรินโน 

ดร. อภิวรรณ อรินโน 

Dr. Apiwan Arinno

 

อาจารย์ประจำ

 

โทรศัพท์ 02-576-6000 ต่อ 7283
Email: [email protected] 

การศึกษา

2023    ปร.ด.   (สรีรวิทยา) 
คณะแพทยศาสตร์ มหาวิทยาลัยเชียงใหม่

2018    วท.ม.   (สรีรวิทยา ) 
คณะแพทยศาสตร์ มหาวิทยาลัยเชียงใหม่

2016    กภ.บ.   (กายภาพบำบัด) 
สำนักวิชาการแพทย์บูรณาการ มหาวิทยาลัยแม่ฟ้าหลวง

ความเชี่ยวชาญ/งานวิจัยที่สนใจ

1. Cardiac electrophysiology

2. Mitochondria biology

3. Tight junction biology

บทความวิชาการ/งานวิจัยที่ได้รับการตีพิมพ์
  1. Arinno A, Sukmak P, Treveeravoot S, Kulworasreth P, Supapol P, Sangsuwan W, Teansuk N, Wachiradejkul W, Inchai J, Sricharunrat T, Jangyubol K, Sanghong P, Vaddhanaphuti CS, Aonbangkhen C, Pongkorpsakol P. (2026). Coffea arabica pulp aqueous extract exhibits the anti-colitogenic effect in mice: preventive efficacy and possible mechanisms of action. Biol Res, https://doi.org/10.1186/s40659-026-00696-9.
  2. Maneechote C, Arinno A, Khuanjing T, Chunchai T, Arunsak B, Shinlapawittayatorn K, Chattipakorn SC, Chattipakorn N. (2026). Ranolazine exerts cardioprotection through attenuating mitochondrial dynamic imbalance in trastuzumab-induced cardiotoxicity in rats. Biochem Pharmacol, https://doi.org/10.1016/j.bcp.2026.117954.
  3. Treveeravoot S, Sukmak P, Chatkul P, Arinno A, Amonsiriwit S, Supapol P, Limwattananon T, Choksukchalalai N, Kitti-Udom N, Chindaduangratn N, Wachiradejkul W, Satianrapapong W, Kwanthongdee J, Moonwiriyakit A, Muanprasat C, Pongkorpsakol P. (2026).Cannabinoid/lysophosphatidylinositol-sensing G-protein coupled receptor 55 promotes intestinal tight junction assembly and its mechanistic insights. Tissue Barriers, https://doi.org/10.1080/21688370.2025.2585726.
  4. Arinno A, Sukmak P, Kulworasreth P, Sricharunrat T, Vaddhanaphuti CS, Pongkorpsakol P. (2025). Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling. Curr Res Pharmacol Drug Discov, https://doi.org/10.1016/j.crphar.2025.100223.
  5. Chatkul P, Satianrapapong W, Wachiradejkul W, Thampathomwong N, Sucharitakul T, Sukmak P, Sirilar P, Lertkiatdamrong P, Chatsiriwech J, Thanasumpunth N, Herabutya P, Arinno A(Corresponding author), Pongkorpsakol P. Cellular mechanisms underlying the effects of sucralose on keratinocyte proliferation and its contributing roles in epidermal regeneration. J Funct Foods. 2025;101:105567.
  6. Sucharitakul T, Chatkul P, Satianrapapong W, Arinno A, Wachiradejkul W, Kittayaruksakul S, Kwanthongdee J, Chatree S, Chatsirisupachai A, Pongkorpsakol P. (2025). Centella asiatica phytochemical Madecassoside enhances skin wound healing and protects against UVB‑induced keratinocyte damage. Tissue Barriers, https://doi.org/10.1080/21688370.2025.2532229.
  7. Chatkul P, Wongsawat M, Satianrapapong W, Arinno A, Lamlertthon P, Wachapatthana U, Sucharitakul T, Wachiradejkul W, Sakulpanich D, Petcharat B, Chancharoen W, Liamsuwan T, Pongkorpsakol P. (2025). An agonist of zinc-sensing g-protein coupled receptor 39 accelerates skin wound healing and protects against UVB-induced keratinocyte damage. J Exp Pharmacol, https://doi.org/10.2147/JEP.S531431.
  8. Maneechote C, Khuanjing T, Ongnok B, Arinno A, Prathumsap N, Chunchai T, Arunsak B, Nawara W, Chattipakorn SC, Chattipakorn N. (2025). Targeting mitochondrial dynamics emerges as an effective strategy of cardioprotection against trastuzumab-induced mitochondrial functional aberrations and cardiotoxicity in rats. Eur J Pharmacol, https://doi.org/10.1016/j.ejphar.2025.177685.
  9. Wachiradejkul W, Sukmak P, Treveeravoot S, Yurasakpong L, Rangchaikul N, Chatkul P, Supapol P, Arinno A, Teansuk N, Jakrachai C, Phummisutthigoon S, Phongjit M, Loungjan A, Akrimajirachoote N, Poolsri W, Aonbangkhen C, Khumjiang R. Muanprasat C, Vaddhanaphuti CS, Pongkorpsakol P. (2024). Enhancing intestinal tight junction assembly by gallic acid as a subcellular basis for the pharmacological effect of Ocimum sanctum L. flower aqueous extract. J Funct Foods. https://doi.org/10.1016/j.jff.2024.106519.
  10. Sukmak P, Kulworasreth P, Treveeravoot S, Arinno A, Anuwongworavet S, Wachiradejkul W, Kulworasreth P, Teansuk N, Thongnak L, Amonlerdpison D, Inchai J, Jakrachai C, Akrimajirachoote N, Aonbangkhen C, Muanprasat C, Poolsri W, Vaddhanaphuti CS, Pongkorpsakol P. (2024). Solanum melongena L. extract promotes intestinal tight junction re-assembly via SIRT-1-dependent mechanisms. Mol Nutr Food Res, https://doi.org/10.1002/mnfr.202400230.
  11. Srivichit B, Thonusin C, Aeimlapa R, Arinno A, Chunchai T, Charoenphandhu N, Chattipakorn N, Chattipakorn SC. (2024). Melatonin and metformin mitigate doxorubicin-induced alveolar bone toxicity. J Dent Res, https://doi.org/10.1177/00220345241261980.
  12. Prathumsap N, Ongnok B, Khuanjing T, Arinno A, Maneechote C, Chunchai T, Arunsak B, Kerdphoo S, Chattipakorn SC, Chattipakorn N. (2024). Muscarinic and nicotinic receptors stimulation by vagus nerve stimulation ameliorates trastuzumab-induced cardiotoxicity via reducing programmed cell death in rats. Toxicol Appl Pharmacol, https://doi.org/10.1016/j.taap.2024.117074.
  13. Arinno A, Maneechote C, Khuanjing T, Prathumsap N, Chunchai T, Arunsak B, Nawara W, Kerdphoo S, Shinlapawittayatorn K, Chattipakorn SC, Chattipakorn N. (2023). Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy. Biochim Biophys Acta Mol Basis Dis, https://doi.org/10.1016/j.bcp.2023.115414.
  14. Khuanjing T, Maneechote C, Ongnok B, Prathumsap N, Arinno A, Chunchai T, Arunsak B, Chattipakorn SC, Chattipakorn N. (2023). Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways. Mol Med, https://doi.org/10.1186/s10020-023-00686-7.
  15. Prathumsap N, Ongnok B, Khuanjing T, Arinno A, Maneechote C, Chunchai T, Arunsak B, Kerdphoo S, Chattipakorn SC, Chattipakorn N. (2023). Acetylcholine receptor agonists effectively attenuated multiple program cell death pathways and improved left ventricular function in trastuzumab-induced cardiotoxicity in rats. Life Sci, https://doi.org/10.1016/j.lfs.2023.121971.
  16. Thonusin C, Nawara W, Arinno A, Khuanjing T, Prathumsup N, Ongnok B, Chattipakorn SC, Chattipakorn N. (2023). Effects of melatonin on cardiac metabolic reprogramming in doxorubicin-induced heart failure rats: A metabolomics study for potential therapeutic targets. J Pineal Res, https://doi.org/10.1111/jpi.12884.
  17. Khuanjing T, Maneechote C, Ongnok B, Prathumsap N, Arinno A, Chunchai T, Arunsak B, Chattipakorn SC, Chattipakorn N. (2023). Vagus nerve stimulation and acetylcholinesterase inhibitor donepezil provide cardioprotection against trastuzumab-induced cardiotoxicity in rats by attenuating mitochondrial dysfunction. Biochem Pharmacol, https://doi.org/10.1016/j.bcp.2023.115836.
  18. Prathumsap N, Ongnok B, Khuanjing T, Arinno A, Maneechote C, Apaijai N, Chunchai T, Arunsak B, Kerdphoo S, Janjek S, Chattipakorn SC, Chattipakorn N. (2022). Vagus nerve stimulation exerts cardioprotection against doxorubicin-induced cardiotoxicity through inhibition of programmed cell death pathways. Cell Mol Life Sci, https://doi.org/10.1007/s00018-022-04678-4.
  19. Chunchai T, Arinno A (Co-first author), Ongnok B, Pantiya P, Khuanjing T, Prathumsap N, Maneechote C, Chattipakorn N, Chattipakorn SC. (2022). Ranolazine alleviated cardiac/brain dysfunction in doxorubicin-treated rats. Exp Mol Pathol, https://doi.org/10.1016/j.neuro.2022.11.012.
  20. Chunchai T, Pintana H, Arinno A, Ongnok B, Pantiya P, Khuanjing T, Prathumsap N, Maneechote C, Chattipakorn N, Chattipakorn SC. (2022). Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain. Neurotoxicology, https://doi.org/10.1016/j.yexmp.2022.104818.
  21. Thonusin C, Nawara W, Khuanjing T, Prathumsup N, Arinno A, Ongnok B, Arunsak B, Sriwichaiin S, Chattipakorn SC, Chattipakorn N. (2022). Blood metabolomes as non-invasive biomarkers and targets of metabolic interventions for doxorubicin and trastuzumab-induced cardiotoxicity. Arch Toxicol, https://doi.org/10.1007/s00204-022-03412-0.
  22. Maneechote C, Khuanjing T, Ongnok B, Arinno A, Prathumsap N, Chunchai T, Arunsak B, Nawara W, Chattipakorn SC, Chattipakorn N. (2022). Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection. Clin Sci, https://doi.org/10.1042/CS20220074.
  23. Prathumsap N, Ongnok B, Khuanjing T, Arinno A, Maneechote C, Apaijai N, Chunchai T, Arunsak B, Shinlapawittayatorn K, Chattipakorn SC, Chattipakorn N. (2021). Acetylcholine receptor agonists provide cardioprotection in doxorubicin-induced cardiotoxicity via modulating muscarinic M2 and α7 nicotinic receptor expression. Transl Res, https://doi.org/10.1016/j.trsl.2021.12.005.
  24. Arinno A, Apaijai N, Chattipakorn SC, Chattipakorn N. (2021). The roles of resveratrol on cardiac mitochondrial function in cardiac diseases. Eur J Nutr, https://doi.org/10.1007/s00394-020-02256-7.
  25. Arinno A, Maneechote C, Khuanjing T, Ongnok B, Prathumsap N, Chunchai T, Arunsak B, Kerdphoo S, Shinlapawittayatorn K, Chattipakorn SC, Chattipakorn N. (2021). Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics. Biochem Pharmacol, https://doi.org/10.1016/j.bcp.2021.114743.
  26. Khuanjing T, Ongnok B, Maneechote C, Siri-Angkul N, Prathumsap N, Arinno A, Chunchai T, Arunsak B, Chattipakorn SC, Chattipakorn N. (2021). Acetylcholinesterase inhibitor ameliorates doxorubicin-induced cardiotoxicity through reducing RIP1-mediated necroptosis. Pharmacol Res, https://doi.org/10.1016/j.phrs.2021.105882.
  27. Chunchai T, Keawtep P, Arinno A, Saiyasit N, Prus D, Apaijai N, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. (2020). A combination of an antioxidant with a prebiotic exerts greater efficacy than either as a monotherapy on cognitive improvement in castrated-obese male rats. Metab Brain Dis, https://doi.org/10.1007/s11011-020-00603-5.
  28. Arinno A, Apaijai N, Kaewtep P, Pratchayasakul W, Jaiwongkam T, Kerdphoo S, Chattipakorn S, Chattipakorn N. (2019). Combination of low-dose testosterone and vildagliptin confers cardioprotection in castrated obese rats. J Endocrinol, https://doi.org/10.1530/JOE-18-0673.
  29. Chunchai T, Keawtep P, Arinno A, Saiyasit N, Prus D, Apaijai N, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. (2019). N-acetyl cysteine, inulin and the two as a combined therapy ameliorate cognitive decline in testosterone-deprived rats. Aging, https://doi.org/10.18632/aging.101989.
  30. Chunchai T, Apaijai N, Keawtep P, Mantor D, Arinno A, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. (2019). Testosterone deprivation intensifies cognitive decline in obese male rats via glial hyperactivity, increased oxidative stress, and apoptosis in both hippocampus and cortex. Acta Physiol, https://doi.org/10.1111/apha.13229.
  31. Keawtep P, Pratchayasakul W, Arinno A, Apaijai N, Chunchai T, Kredphoo S, Jaiwongkum T, Chattipakorn N, Chattipakorn SC. (2019). Combined dipeptidyl peptidase-4 inhibitor with low-dose testosterone exerts greater efficacy than monotherapy on improving brain function in orchiectomized obese rats. Exp Gerontol, https://doi.org/10.1016/j.exger.2019.05.008.
  32. Apaijai N, Arinno A, Palee S, Pratchayasakul W, Kerdphoo S, Jaiwongkam T, Chunchai T, Chattipakorn SC, Chattipakorn N. (2019). High-saturated fat high-sugar diet accelerates left-ventricular dysfunction faster than high-saturated fat diet alone via increasing oxidative stress and apoptosis in obese-insulin resistant rats. Mol Nutr Food Res, https://doi.org/10.1002/mnfr.201800729.
การนำเสนอผลงานวิชาการ
  1. The American College of Cardiology’s 71st Annual Scientific Session & Expo (ACC), 2-4 April 2022, Washington, D.C., USA. Poster presentation: Ranolazine administration effectively alleviates trastuzumab-induced cardiotoxicity through modulation of mitochondrial function in rats
  2. American Heart Association (AHA) 2021, 13-15 November 2021, Online. Poster presentation: Melatonin and Metformin exert cardioprotection against trastuzumab-induced cardiotoxicity through modulating cardiac mitochondrial dynamics in rats.
  3. European Society of Cardiology (ESC) Congress 2021, 27-30 August 2021, Online, Poster presentation: Melatonin, Metformin, and Ranolazine protect heart against doxorubicin-induced cardiotoxicity through modulating cardiac mitochondrial dynamics in rats.